For administration of the oral solution with continuous enteral nutrition, some experts recommend that the tube feeding should be interrupted for one hour before and two hours after the dose of levofloxacin. According to the drug product labeling, administration of levofloxacin 500 mg with food prolonged the time to peak concentration by 1 hour and decreased the Cmax decreased by 25% following administration of the oral solution and by 14% following administration of the oral tablet. Based on the American Thoracic Society, CDC, and IDSA guidelines for the treatment of tuberculosis, levofloxacin is an effective and recommended alternative agent for treatment of drug-resistant tuberculosis caused by sensitive organisms or when first-line agents are intolerable. Based on the IDSA guidelines for the management of prosthetic joint infection, levofloxacin, in combination with rifampin, is an effective and recommended agent for oral phase treatment of prosthetic joint infection with staphylococci after completion of parenteral therapy. Based on the CDC sexually transmitted diseases treatment guidelines, levofloxacin, in combination with metronidazole, may be considered as alternative treatment in patients allergic to cephalosporins with pelvic inflammatory disease.
Pseudomonas aeruginosa Pulmonary Infections (Orphan)
Get emergency medical help if you have severe and constant pain in your chest, stomach, or back. Levofloxacin can cause serious side effects, including tendon problems, side effects on your nerves (which may cause permanent nerve damage), serious mood or behavior changes (after just one dose), or low blood sugar (which can lead to coma). Tell your healthcare provider about any side effect that bothers you or that does not go away. If you take too much, call your healthcare provider or get medical help immediately. Microbiologic eradication rates in the Microbiologically Evaluable population at TOC for individual pathogens recovered from patients randomized to LEVAQUIN® treatment are presented in Table 21. Levofloxacin has been shown to be active against Bacillus anthracis both in vitro and by use of plasma levels as a surrogate marker in a rhesus monkey model for anthrax (post-exposure) see Indications and Usage (1.13), Clinical Studies (14.9).
LEVAQUIN Injection in Single-Use Vials
Following oral administration, approximately 87% of an administered dose was recovered as unchanged drug in urine within 48 hours, whereas less than 4% of the dose was recovered in feces in 72 hours. Less than 5% of an administered dose was recovered in the urine as the desmethyl and N-oxide metabolites, the only metabolites identified in humans. The usual dose of levofloxacin tablets is 250 mg, 500 mg, or 750 mg administered orally every 24 hours, as indicated by infection and described in Table 1. Levofloxacin tablets are indicated for the treatment of uncomplicated urinary tract infections (mild to moderate) due to Escherichia coli, Klebsiella pneumoniae, or Staphylococcus saprophyticus. Levofloxacin tablets are indicated for the treatment of uncomplicated skin and skin structure infections (mild to moderate) including abscesses, cellulitis, furuncles, impetigo, pyoderma, wound infections, due to methicillin-susceptible Staphylococcus aureus, or Streptococcus pyogenes. Levofloxacin tablets are indicated for the treatment of acute bacterial exacerbation of chronic bronchitis due to methicillin-susceptible Staphylococcus aureus, Streptococcus pneumoniae, Haemophilus influenzae, Haemophilus parainfluenzae, or Moraxella catarrhalis.
Dosage for pneumonia
Prolonged use may result in overgrowth of non-susceptible organisms, including fungi. If superinfection occurs, discontinue use and institute alternative therapy. Patients should be advised not to wear contact lenses if they have signs and symptoms of corneal ulcer. Avoid levofloxacin oral route proper use contaminating the applicator tip with material from the eye, fingers or other source.
Important Administration Instructions
Patients with AP complicated by underlying renal diseases or conditions such as complete obstruction, surgery, transplantation, concurrent infection or congenital malformation were excluded. Efficacy was measured by bacteriologic eradication of the baseline organism(s) at the post-therapy visit in patients with a pathogen identified at baseline. The post-therapy (test-of-cure) visit occurred 10 to 14 days after the last active dose of levofloxacin and 5 to 9 days after the last dose of active ciprofloxacin. There are no significant differences in levofloxacin pharmacokinetics between young and elderly subjects when the subjects’ differences in creatinine clearance are taken into consideration. Following a 500 mg oral dose of levofloxacin to healthy elderly subjects (66 to 80 years of age), the mean terminal plasma elimination half-life of levofloxacin was about 7.6 hours, as compared to approximately 6 hours in younger adults. The difference was attributable to the variation in renal function status of the subjects and was not believed to be clinically significant.
Before taking levofloxacin, tell your health care provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. Tell your health care provider if you are taking levofloxacin before you get a urine drug screen. Talk to your health care provider about how to maintain healthy blood sugar levels while you are taking this medicine. Tell your health care provider if you have ever had swelling or a tear in the large artery that carries blood from the heart, called the aorta.
- Several additional glasses of water should be taken every day, unless otherwise directed by your doctor.
- The medication can affect blood sugar levels, sometimes causing them to go too high or too low, especially in people taking diabetes medications.
- LEVAQUIN is indicated for the treatment of chronic bacterial prostatitis due to Escherichia coli, Enterococcus faecalis, or methicillin-susceptible Staphylococcus epidermidis see Clinical Studies (14.6).
The appearance of LEVAQUIN® Oral Solution may range from clear yellow to clear greenish-yellow. LEVAQUIN® should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. The drug should be discontinued immediately at the first appearance of skin rash, jaundice, or any other sign of hypersensitivity and supportive measures instituted see Adverse Reactions (6); Patient Counseling Information (17.3). LEVAQUIN® Injection is also supplied in flexible containers within a foil overwrap. These contain a premixed, ready to use levofloxacin solution in 5% dextrose (D5W) for single-use. The 100 mL premixed flexible containers contain either 250 mg/50 mL or 500 mg/100 mL of levofloxacin solution.
LEVAQUIN® can cause side effects that may be serious or even cause death. If you get any of the following serious side effects, get medical help right away. Talk with your healthcare provider about whether you should continue to take LEVAQUIN®. Clinical success rates in clinically and microbiologically evaluable patients at the posttherapy visit (primary study endpoint assessed on day 3–15 after completing therapy) were 58.1% for LEVAQUIN® and 60.6% for comparator. The 95% CI for the difference of response rates (LEVAQUIN® minus comparator) was -17.2, 12.0.
Susceptible organisms
Ceftriaxone is used for bacteremia, bacterial endocarditis prevention, bacterial infection, bone … Augmentin is a prescription antibiotic combining amoxicillin and clavulanate to treat bacterial … Clindamycin (Cleocin) is used to treat serious infections caused by bacteria. Amoxicillin and clavulanate potassium is a combination antibiotic used to treat bacterial … Avoid driving or hazardous activity until you know how levofloxacin will affect you.
- However, elderly patients are more likely to have age-related tendon disorders (including tendon rupture) and kidney, liver, or heart problems, which may require caution and an adjustment in the dose for patients receiving levofloxacin.
- Levofloxacin tablets are indicated in adult patients for the treatment of complicated urinary tract infections due to Escherichia coli, Klebsiella pneumoniae, or Proteus mirabilis see Clinical Studies (14.7).
- If you remember relatively close to the time you take your next dose then you should skip the missed dose.
- Your doctor might adjust the treatment length based on how you respond to the medication and whether your symptoms improve.
- There are, however, no adequate and well-controlled studies in pregnant women.
- This includes prescription or nonprescription (over-the-counter OTC) medicines and herbal or vitamin supplements.
Use levofloxacin for the full prescribed length of time, even if your symptoms quickly improve. Skipping doses can increase your risk of infection that is resistant to medication. Levofloxacin will not treat a viral infection such as the flu or a common cold.